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COMBINATION TUMOR TREATMENT WITH DRUG-LOADED, BISPECIFIC LIGAND-TARGETED MINICELLS AND INTERFERON-GAMMA
专利权人:
ENGENEIC MOLECULAR DELIVERY PTY LTD
发明人:
BRAHMBHATT HIMANSHU,MACDIARMID JENNIFER
申请号:
AP2016009153
公开号:
AP2016009153A0
申请日:
2014.10.03
申请国别(地区):
AP
年份:
2016
代理人:
摘要:
Compositions and methods are provided for cancer treatments. The methodology entails, for instance, administering to a cancer patient a first composition comprising a plurality of bacterially derived intact minicells or intact killed bacterial cells, each of which encompasses an anti-neoplastic agent and carries a bispecific ligand on the surface, the ligand having specificity for a mammalian cell component, and a second composition comprising interferon-gamma (IFN-gamma) or an agent that increases the expression of IFN-gamma in the subject. The compositions include the first composition and the second composition as described, optionally with additional anti-neoplastic agents.
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