The basic formulation comprises a combination of three estrogens, 2-hydroxyestrone, 17-beta-estradiol and estriol, and a metabolite of an estrogen, 2-methoxyestradiol, in specified amounts. Amounts of folic acid, DHEA, testosterone, Vitamin B6, Di-Indolyl Methane, melatonin and progesterone, as well as selenium and cobalt can be added in specific amounts to the basic formulation. 2-Hydroxyestradiol, another metabolic, can also be added.本發明係關於一種基底調配物,該基底調配物包括特定量之三種雌激素(2-羥基雌甾酮、17-β-雌二醇及雌三醇)以及雌激素代謝物(2-甲氧基雌二醇)的組合。亦可在該基底調配物中添加某量之葉酸、DHEA、睪固酮、維生素B6、二-吲哚基甲烷、褪黑激素及黃體酮、以及特定量之硒和鈷。也可添加2-羥基雌二醇(另一種代謝物)。