MAGLIONE, DOMENICO,BATTISTI, MAURO,CONTI, ETTORE,SALVIA, GIUSEPPE,TUCCI, MARINA,MION, ALBERTO
申请号：
CA2485587
公开号：
CA2485587C
申请日:
2003.05.19
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The present invention relates to chemically stable muteins of type 1 PlacentalGrowth Factor (PLGF-1) bearing the substitution or elimination of a cysteineresidue from the wild type protein amino acid sequence, their preparation,their therapeutic and cosmetic uses, and pharmaceutical and cosmeticcompositions containing said derivatives. The invention likewise relates tothe production of antibodies for said derivatives and their use in thediagnosis and treatment of tumoral and non-tumoral pathologies.
