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USE OF TETRA-SUBSTITUTED DERIVATIVES [4,3-D] PYRIMIDINE FOR TREATMENT OF DIABETIC NEPHROPATHY
专利权人:
ПФАЙЗЕР ИНК. (US)
发明人:
КЛЕРИН Валери (US),ГЕЙЛ Джереми (US),ТАМИМИ Найхэд (GB)
申请号:
RU2015115005
公开号:
RU2015115005A
申请日:
2013.10.09
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1.1- (2-Ethoxyethyl) -5- (ethyl (methyl) amino) -7 - ((4-methylpyridin-2-yl) amino) -N- (methylsulfonyl) -1H-pyrazolo [4,3-d ] pyrimidine-3-carboxamide, or a pharmaceutically acceptable salt thereof, for use in the treatment of end-stage chronic renal failure. 1- (2-Ethoxyethyl) -5- (ethyl (methyl) amino) -7 - ((4-methylpyridin-2-yl) amino) -N- (methylsulfonyl) -1H-pyrazolo [4,3-d] pyrimidine -3-carboxamide, or a pharmaceutically acceptable salt thereof, and at least one carrier, diluent or excipient for use in the treatment of end-stage chronic renal failure. 3. 1- (2-Ethoxyethyl) -5- (ethyl (methyl) amino) -7 - ((4-methylpyridin-2-yl) amino) -N- (methylsulfonyl) -1H-pyrazolo [4,3-d] pyrimidine -3-carboxamide, or a pharmaceutically acceptable salt thereof, for use in the treatment of diabetic nephropathy. 4. 1- (2-Ethoxyethyl) -5- (ethyl (methyl) amino) -7 - ((4-methylpyridin-2-yl) amino) -N- (methylsulfonyl) -1H-pyrazolo [4,3-d] pyrimidine -3-carboxamide, or a pharmaceutically acceptable salt thereof, and at least one carrier, diluent or excipient for use in the treatment of diabetic nephropathy. 5. 1- (2-Ethoxyethyl) -5- (ethyl (methyl) amino) -7 - ((4-methylpyridin-2-yl) amino) -N- (methylsulfonyl) -1H-pyrazolo [4,3-d] pyrimidine -3-carboxamide or a pharmaceutically acceptable salt thereof, for use in the treatment of chronic kidney disease. 6. The use of claim 5, wherein the chronic kidney disease is stage 3 or 4.7. 1- (2-ethoxyethyl) -5- (ethyl (methyl) amino) -7 - ((4-methylpyridin-2-yl) amino) -N- (methylsulfonyl) -1H-pyrazolo [4,3-d] pyrimidine -3-carboxamide, or a pharmaceutically acceptable salt thereof, and at least one carrier, diluent or excipient for use in the treatment of chronic kidney disease. The use of claim 7, wherein the chronic kidney disease is stage 3 or 4.9.1. 1-(2-Этоксиэтил)-5-(этил(метил)амино)-7-((4-метилпиридин-2-ил)амино)-N-(метилсульфонил)-1Н-пиразоло[4,3-d]пиримидин-3-карбоксамид, или его фармацевтически приемлемая соль, для примен
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