DERIVES D'INDENOINDOLE, SELS PHARMACEUTIQUEMENT ACCEPTABLES OU ISOMERES OPTIQUES DE CEUX-CI, LEUR PROCEDE DE PREPARATION ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT EN TANT QUE PRINCIPE ACTIF POUR LA PREVENTION OU LE TRAITEMENT DE MALADIES VIRALES
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY;KATHOLIEKE UNIVERSITEIT LEUVEN K.U. LEUVEN R & D
发明人:
JUNG, YOUNG SIK,LEE, CHONG KGO,KIM, HAE SOO,JEONG, HEE CHUN,KIM, PIL HO,HAN, SOO BONG,NEYTS, JOHAN,THIBAUT, HENDRIK JAN,SHIN, JIN SOO
申请号：
CA2984974
公开号：
CA2984974A1
申请日:
2012.06.18
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The present invention relates to a indanonederivative, pharmaceutically acceptable salts or opticalisomers thereof, a preparation method for same, and apharmaceutical composition containing same as an activeingredient for preventing or treating viral diseases. Theindanone derivatives according to the present invention notonly have low cyto-toxicity, but may also demonstrateutility as pharmaceutical compositions for preventing ortreating viral diseases such as: polio, viral paralysis,acute hemorrhagic conjunctivitis, viral meningitis,handfoot-mouth disease, blistering diseases, hepatitis A,myositis, myocarditis, pancreatitis, viral diabetes,epidemic myalgia, encephalitis, flu, herpes angina,foot-and-mouth disease, asthma, chronic obstructive pulmonarydisease, pneumonia, sinusitis, otitis media, and the like,since excellent antiviral activity against picornavirusessuch as Coxsack - ie virus, enterovirus, echovirus, poliovirus, rhinovirus, and the like, have been demonstrated.Indanone derivatives include those represented by formula1:(see formula 1)wherein,A1, A2, A3, A4, D, E, Z, G1, G2, G3, G4, X, and Y arerespectively as defined herein.
