ZABLOCKI, JEFF,MISH, MICHAEL R.,MACKMAN, RICHARD L.,CHIN, GREGORY
申请号：
ARP170102436
公开号：
AR109560A1
申请日:
2017.09.01
申请国别(地区):
AR
年份:
2018
代理人:
摘要：
This request generally relates to toll type receivers and modulation compounds of pharmaceutical compounds, including, inter Alia, toll type receivers (such as tlr8),There are also ways to make and use them 1. Characteristic requirement 1: a formula compound (1) or a salt acceptable on the medicament, wherein: R1 es-h, asphalt c833318324；or C₁₋₄ haloalkyl；R2 is c83217c833118326 or c8331268halogelo c83326262；R³ is C₁₋₄ alkoxide optionally substituted with 1 RX； each RX is independently -ORY, 5- to 6-membered heterocyclyl having 1 to 3 heteroatoms selected from oxygen, nitrogen and sulfur optionally substituted with 1 to 3 RZ； phenyl optionally substituted with 1 to 3 RZ； or 5- to 6-membered heteroaryl having 1 to 3 heteroatoms selected from oxygen, nitrogen and sulfur optionally substituted with 1 to 3 RZ； RY is C₁₋₄ alkyl,haloalkyl C₁₋₄,The heteromorphism of O 5 to 10 members consists of 1 to 3 heteroatoms selected from oxygen, nitrogen and optional sulfur, replaced by 1 to 3 RZ； q is n, CH, ocr8308；or R³ and R⁴ are taken together to form C₅₋₆ cycloalkyl；a. Isopropene of 5 to 6 members, including 1 to 3 heteroatoms selected from oxygen, nitrogen and sulfur； phenyl； or heteroatoms of 5 to 6 members, including 1 to 3 heteroatoms selected from oxygen, nitrogen and sulfur；Phenyl was replaced by 1-3r83099；Each r83099 is a separate halogen - Oh, n832222,-CN, C₁₋₄ alkyl optionally substituted with 1 to 3 RZ, C₁₋₄ haloalkyl,C₁₋₄ alkoxide,-C (O) OH, -C (O) C₁₋₄ alkyl,-C (O) O-C₁₋₄-alkyl,-C (O) NH-C (o) NH (lease No. c832131)-C (O) N (C₁₋₄ alkyl) ₂,-N (H) C (O) C₁₋₄ alkyl,-S (O) ₂alkyl C₁₋₄,O heteromorphism consisting of 5 to 6 members, 1 to 3 oxygen, nitrogen and sulfur selected from non living organisms, replaced by 1 to 3 RZ； heteromorphism consisting of 5 to 6 members, replaced by 1 to 3 r8310；Each r83100s is an independent halogen-CN, C₁₋₄-alkyl optionally substituted with 1 phenyl optionally substituted with 1 to 3 RZ； haloalkyl C₁₋₄,C₁₋₄ alkoxide,-S (O) ₁₋₄ alkyl C₁₋₄；
