LYNN, MACDONALD,SEAN, STEVENS,CAGAN, GURER,ANDREW J. , MURPHY,KAROLINA A. , HOSIAWA
申请号：
MYPI 2012005501
公开号：
MY157477A
申请日:
2011.06.22
申请国别(地区):
MY
年份:
2016
代理人:
摘要：
GENETICALLY MODIFIED MICE ARE PROVIDED THAT EXPRESS HUMAN l VARIABLE (HVl) SEQUENCES, INCLUDING MICE THAT EXPRESS HVl SEQUENCES FROM AN ENDOGENOUS MOUSE l LIGHT CHAIN LOCUS, MICE THAT EXPRESS HVl SEQUENCES FROM AN ENDOGENOUS MOUSE K LIGHT CHAIN LOCUS, AND MICE THAT EXPRESS HVX SEQUENCES FROM A TRANSGENE OR AN EPISOME WHEREIN THE HVl, SEQUENCE IS LINKED TO A MOUSE CONSTANT SEQUENCE. MICE ARE PROVIDED THAT ARE A SOURCE OF SOMATICALLY MUTATED HUMAN l VARIABLE SEQUENCES USEFUL FOR MAKING ANTIGEN-BINDING PROTEINS. COMPOSITIONS AND METHODS FOR MAKING ANTIGEN-BINDING PROTEINS THAT COMPRISE HUMAN l VARIABLE SEQUENCES, INCLUDING HUMAN ANTIBODIES, ARE PROVIDED.
