DEVICE FOR TRANSIENTLY CONTACTING AT LEAST ONE UNIT FOR CAPTURING BIOLOGICAL TARGETS WITH A FLUID CONTAINING THEM, METHOD FOR RECOVERING THE CAPTURED TARGETS AND SYSTEM FOR CONTACTING AND RECOVERY
The invention relates to a device for transiently contacting at least one unit for capturing biological targets with a body fluid containing them, a method for recovering the captured targets for analysis, and a system for contacting and recovering a capture substrate included in said unit. The invention relates to samples obtained in particular in vivo from body fluids of the human body, e.g. circulating body fluids, said fluids possibly containing, as targets, proteins, oligonucleotides such as RNA or DNA, antibodies, enzymes or cells. A contacting device (1) according to the invention comprises: - a sampling tip (2) having a contacting end intended to be introduced into a medium containing said fluid, and - the or each capturing unit which is bound to said end and which comprises a capture substrate (3) defining a target capturing surface covered with at least one biocompatible and porous crosslinked polymer layer (4) designed to retain the or each capture substrate and only to allow biological particles including targets smaller than a limiting size to pass through, in such a way that the or each capture substrate is recoverable after said contacting by dissolution of the or each layer.Linvention concerne un dispositif pour mettre en contact de façon transitoire au moins une unité pour capturer des cibles biologiques avec un fluide corporel contenant celles-ci, un procédé pour récupérer les cibles pour analyse, et un système pour mettre en contact et récupérer un substrat de capture compris dans ladite unité. Linvention concerne des échantillons obtenus en particulier in vivo à partir de fluides corporels du corps humain, par exemple des fluides corporels circulants, lesdits fluides contenant éventuellement, en tant que cibles, des protéines, des oligonucléotides tels quun ARN ou un ADN, des anticorps, des enzymes ou des cellules. Un dispositif de mise en contact (1) selon linvention comprend :- une pointe déchantillonnage (2) ayant une extrémité de mise en cont
