The invention provides an anti-tumor drug with excellent anti-tumor effect and safety and excellent therapeutic effect. The invention provides an antibody drug conjugate, which is characterized in that the anti-tumor compound expressed in the following formula and the anti-trop2 antibody are connected by the connector of the structure represented by the formula: - l1-l2-lp-nh - (CH2) n1-la - (CH2) n2-c (= O) - (the anti-trop2 antibody is connected to the end of L1, and the anti-tumor compound is connected to - (CH2) n2-c (= O) with the nitrogen atom of 1-amino as the connecting site- Part of the carbonyl group).本發明提供一種抗腫瘤效果和安全性方面優異的、具有優異的治療效果的抗腫瘤藥。本發明提供一種抗體－藥物偶聯物，其特徵在於，其是將下式表示的抗腫瘤性化合物與抗TROP2抗體介由下式：-L1-L2-LP-NH-(CH2)n1-La-(CH2)n2-C(=O)-表示的結構的接頭連接而成的(抗TROP2抗體連接於L1的末端，抗腫瘤性化合物以1位的氨基的氮原子為連接部位、連接於-(CH2)n2-C(=O)-部分的羰基)。
