Method and apparatus for detecting and analyzing heart mechanical activity at a region of interest of a patients heart are provided. The method comprises acquiring a time sequence of 2-dimensional X-ray images of a region of interest over at least part of a cardiac cycle detecting coronary vessels in the X-ray images tracking the coronary vessels through the sequence of images to identify movements of the coronary vessels and analyzing the movements of the coronary vessels to quantify at least one parameter characterizing heart wall motion in the region of interest.
