1,3-DIHYDROIMIDAZOLE-2-THIONE DERIVATIVES FOR USE IN THE TREATMENT OF PULMONARY ARTERIAL HYPERTENSION AND LUNG INJURY

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专利权人:

BIAL - Portela & Ca.; S.A.

发明人:

Soares Da Silva, Patrício Manuel Vieira Araújo,Soares Da Silva, PatrĂ­cio Manuel Vieira AraĂşjo,Bonifácio, Maria João Macedo da Silva,Bonifácio, Maria JoĂŁo Macedo da Silva

申请号：

HRP20181651

公开号：

HRP20181651T1

申请日:

2018.10.11

申请国别(地区):

HR

年份:

2018

代理人:

摘要：

The present invention relates to compounds of formula I: for use in treating pulmonary arterial hypertension and associated conditions, where R1, R2 and R3 are the same or different and signify hydrogens, halogens, alkyl, alkylaryl, alkyloxy, hydroxy, nitro, amino, alkylcarbonylamino, alkylamino or dialkylamino group R4 signifies hydrogen, alkyl, -alkylaryl or -alkylheteroaryl X signifies CH2, oxygen atom or sulphur atom n is 1, 2 or 3, with the proviso that when n is 1, X is not CH2 and the individual (R)- and (S)-enantiomers or mixtures of enantiomers and pharmaceutically acceptable salts thereof.

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中国工程科技知识中心

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http://www.ckcest.cn/home/