Discloses a protein complex in the form of a synthetic chimeric protein comprising an amino acid sequence of (I) an insulin-like growth factor (IGF, IGF-I or IGF-II) or at least a domain of said insulin-like growth factor which is capable of binding a cognate insulin-like growth factor receptor and (II) one or more type-III domains of fibronectin (FN3) comprising at least an integrin-binding domain of FN3； wherein the complex is suitable for stimulating cell migration and/or proliferation
