CORNFORD-NAIRN, RENEE,DAGGARD, GRANT EDWARD,MUKKUR, TRILOCHAN KANWALJIT SINGH,ROSSETTI, TONY ROBERT
申请号：
CA2475993
公开号：
CA2475993C
申请日:
2002.12.30
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The present invention discloses the structure and sequence ofaroQ fromBordetella pertussis, which are usefulinter alia for the production of thegenetically modified attenuated Bordetella strains of the present inventionand for detecting and isolating variant aroQ genes and expression products.The present invention also discloses attenuatedBordetella strains ofpathogenic origin, and more particularly genetically modified Bordetellastrains, which have been attenuated by disruption or inactivation of the aroQgene. The genetically modified Bordetella strain of the present invention hasa reduced capacity to propagate in a mammalian host, but remains viable in thehost for a period of time sufficient to induce a protective immune responseagainst the natural pathogenic Bordetella counterpart. The present inventionis also directed to the use of such genetically modified Bordetella strains inimmunopotentiating compositions for treating and/or preventing inter aliaBordetella infections, and particularly pathogenic infections, caused byBordetella.
