Substituted benzofuranyl and benzoxazoles based compound and application thereof农业专利-农业专业知识服务系统

专利权人:: INC.;KARYOPHARM THERAPEUTICS;KARYOPHARM THERAPEUTICS, INC.;卡尔约药物治疗公司;卡爾約藥物治療公司

发明人:: E．巴罗格鲁,E．巴羅格魯,S．沙查姆,W．塞纳佩迪斯,W．塞納佩迪斯,D．麦考利,D．麥考利,Y．兰德斯曼,Y．蘭德斯曼,G．格兰,G．格蘭,O．卡利德,S．谢克特尔,S．謝克特爾,E.巴罗格鲁,E.巴羅格魯,S.沙查姆,W.塞纳佩迪斯,W.塞納佩迪斯,D.麦考利,D.麥考利,Y.兰德斯曼,Y.蘭德斯曼,G.格兰,G.格蘭,O.卡利德,S.谢克特尔,S.謝克特爾

摘要：: Generally, the present invention relates to substituted benzofuranyls and substituted benzoxazoles based compound, and relate more specifically to the compound or its pharmaceutically acceptable salt that are indicated by structural formula (A), and wherein these variables are as defined herein and to describe. The invention also includes the synthesis of compound or its pharmaceutically acceptable salt or composition with structural formula (A) and the purposes in such as treating cancer (for example, lymphoma mantle cell) and other diseases and disorder.總體上，本發明涉及取代的苯并呋喃基和取代的苯并噁唑基化合物，並且更具體地涉及由結構式(A)表示的化合物或其藥學上可接受的鹽，其中這些變量是如在此定義和描述的。本發明還包括具有結構式(A)的化合物或其藥學上可接受的鹽或組合物的合成和在例如治療癌症（例如，套細胞淋巴瘤）和其他疾病及紊亂中的用途。