ARBABI-GHAHROUDI, MEHDI,RIAZI, ALI,SZYMANSKI, CHRISTINE M.,HUSSACK, GREG,TANHA, JAMSHID,MACKENZIE, ROGER
申请号：
CA2889398
公开号：
CA2889398A1
申请日:
2013.10.24
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
Campylobacter jejuni is a leading cause of bacterial food-borne diseases in humans, ranging from acute diarrheal disease to neurological disorders. An isolated or purified antibody or fragment thereof specific to C. jejuni is described. The antibody or fragment thereof binds to a flagellar protein and reduces motility of C. jejuni. The antibody or fragment thereof is derived from a heavy chain IgG variable domain fragment (VHH) of a camelid animal immunized with C. jejuni flagellar protein. A multivalent form, as well as a phage format, of the antibody or fragment thereof is described. Methods of reducing presence of C. jejuni in an animal or an animal environment, methods and formulations for treating C. jejuni infection, and method of detecting C. jejuni are also described.
