The Government of the U.S.A. as rep. by the Secretary of the Dept. of Health and Human Services
发明人:
Gwong-Jen J. Chang,Wayne D. Crill,Holly R. Hughes,Brent S. Davis
申请号：
US16745986
公开号：
US20200147201A1
申请日:
2020.01.17
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Described herein are dengue virus E-glycoprotein polypeptides containing mutations that eliminate immunodominant cross-reactive epitopes associated with immune enhancement. The disclosed dengue virus E-glycoproteins optionally further include mutations that introduce a strong CD4 T cell epitope. The disclosed E-glycoprotein polypeptides, or nucleic acid molecules encoding the polypeptides, can be used, for example, in monovalent or tetravalent vaccines against dengue virus.
