Srinivansan Venkateshwaran;Chandrashekar Giliyar;Chidambaram Nachiappan;Satish Kumar Nachaegari;Mahesh V. Patel
发明人:
Chandrashekar Giliyar,Satish Kumar Nachaegari,Chidambaram Nachiappan,Mahesh V. Patel,Srinivansan Venkateshwaran
申请号：
US13342883
公开号：
US20130172381A1
申请日:
2012.01.03
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The disclosed invention is drawn to pharmaceutical tablets that provide delivery of active agents having at least three oxygen-containing groups, as well as a second active ingredient. Non-limiting examples of three oxygen-containing group active agents include guaifenesin, codeine, hydrocodone, and their pharmaceutically acceptable salts. In one embodiment, a pharmaceutical tablet for oral administration once every 12 hours is provided. The tablet includes a first active agent that is a tri-oxy active agent, a second active agent, and a release rate controlling non-ionic oxyl-containing hydrophilic polymer. The total oxyl content of the hydrophilic polymer in the tablet is about 4×10−4 moles to about 2.0×10−3 moles.
