Ananth V. ANNAPRAGADA,Peter NILSSON,Carlo MEDICI,Eric A. TANIFUM
申请号：
US16751943
公开号：
US20200261605A1
申请日:
2020.01.24
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Phospholipid-polymer-aromatic conjugates comprising binding ligands, liposome compositions including the phospholipid-polymer-aromatic conjugates, and binding ligands having an affinity for misfolded proteins are described. The phospholipid-polymer-aromatic conjugate may be represented by Structural Formula I: PL-AL-HP-X-BL (I). In Formula I, PL is a phospholipid, AL is an aliphatic linkage, HP is hydrophilic polymer, X is a link between the phospholipid-polymer and the binding ligand, and BL is polycyclic aromatic compound that functions as a binding ligand. The liposomal compositions may be useful for the imaging of misfolded and/or aggregated proteins.
