REIC-EXPRESSING ADENOVIRUS VECTOR

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专利权人:

发明人:

申请号：

EP12789513.4

公开号：

EP2716756A1

申请日:

2012.05.25

申请国别(地区):

EP

年份:

2014

代理人:

摘要：

An objective of the present invention is to provide an adenovirus vector expressing a REIC/Dkk-3 protein at a high level and containing a DNA construct for expression of REIC/Dkk-3 DNA, wherein the DNA construct is prepared by ligating, from the 5 terminal side,(i) a CMV promoter,(ii) REIC/Dkk-3 DNA,(iii) a poly A addition sequence, and(iv) enhancers prepared by linking an hTERT (Telomerase Reverse Transcriptase) enhancer, an SV40 enhancer, and a CMV enhancer in this order.

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