Disclosed herein are compositions and methods for regulating redox status and/of reducing oxidative stress in a subject, the methods and compositions comprising TLR agonists comprising bacterial lysates and/or lysate fractions. Also disclosed are compositions and methods comprising bacterial lysates and/or lysate fractions formulated or administered in combination with one or more other therapeutic or pharmaceutical agents.En la presente se divulgan composiciones y metodos para la regulacion del estado redox y/o reduccion del estres oxidativo en un sujeto, los metodos y composiciones que comprenden agonistas de TLR que comprenden lisados y/o fracciones de lisados bacterianos. Ademas, se divulgan composiciones y metodos que comprenden lisados y/o fracciones de lisados bacterianos formulados o administrados en combinacion con uno o mas agentes terapeuticos o farmacéuticos diferentes.