LIPOSOMES HYPERSTABILISES AUGMENTANT LE CIBLAGE DE CELLULES MITOTIQUES

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专利权人:

TEMASEK LIFE SCIENCES LABORATORY LIMITED

发明人:

NG, CHANG ZHI ADRIAN,CHEONG, SHEN-YI IAN

申请号：

CA3050686

公开号：

CA3050686A1

申请日:

2018.01.17

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

Hyperstable liposome comprising an anti-mitotic agent, one or more anions and one or more cations entrapped in the inner milieu, wherein the entrapped anti-mitotic drug is released at a slow rate that is less than 0.6% in 12 hours or less than 5% in 8 hours when the liposomes are suspended in 600mM sucrose. These liposomes are useful in the treatment of cancer. In particular, HEPC:Chol:DSPE-PEG2000 (50:45:5) liposomes comprising BI 2536 and citrate:phosphate in a ratio of 1 :3.

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