Patrick Henry Maxwell,Christopher William Pugh,Peter John Ratcliffe,Christopher Joseph Schofield
申请号：
US15853103
公开号：
US20180271850A1
申请日:
2017.12.22
申请国别(地区):
US
年份:
2018
代理人:
摘要：
A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the HIF hydroxylase with a substrate. Modulators of HIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.
