Disc pump systems and methods relate to a disc pump system that includes a first disc pump having a first actuator and a second disc pump having a second actuator. The systems and methods utilize sensors to measure the displacements of the actuators and a processor to determine the pressure differential across each actuator as a function of the measured displacements of the actuators. The disc pumps are fluidly coupled by a known restriction and the processor determines the flow rate of the disc pump system based on the determined pressure differentials across each actuator and the characteristics of the known restriction.