PROBLEM TO BE SOLVED: To provide a medicament comprising as an active ingredient a sustained human growth hormone preparation having suppressed prolactin-like activity and having a long half-life in the blood as compared with 22K human growth hormone.SOLUTION: According to the present invention, there is provided a fusion protein comprising a human serum albumin part and a 20 K human growth hormone part, the fusion protein having growth promoting activity. In particular, there is provided a fusion protein in which a 20 K human growth hormone part is bound to the C-terminal side of the human growth hormone part via a linker sequence.SELECTED DRAWING: Figure 1COPYRIGHT: (C)2017,JPO&INPIT【課題】22Kヒト成長ホルモンと比較して,プロラクチン様活性が抑制され,且つ血中での半減期が長い持続型のヒト成長ホルモン製剤を有効成分として含有してなる薬剤を提供すること。【解決手段】ヒト血清アルブミン部と20Kヒト成長ホルモン部を有する融合タンパク質であって,成長促進活性を有する融合タンパク質。特に,ヒト成長ホルモン部のC末端側にリンカー配列を介して20Kヒト成長ホルモン部が結合したものである,融合タンパク質。【選択図】図1
