WANG PEIYUAN,SOFIA MICHAEL JOSEPH,PAMULAPATI GANAPATI REDDY,ZHANG HAI-REN,CHUN BYOUNG-KWON,ROSS BRUCE S.,RACHAKONDA SUGUNA
申请号:
NZ62360210
公开号:
NZ623602A
申请日:
2010.05.20
申请国别(地区):
NZ
年份:
2015
代理人:
摘要:
Disclosed is the enantiomeric purification of (S)-2-[(S)-(4-nitro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester and its analogues as useful synthetic intermediates in the enantiomerically pure synthesis of sofosbuvir. Also disclosed are compounds of general formula C and C’, wherein R is a leaving group (LG’) selected from tosylate, camphorsulfonate, an aryloxide, or an aryloxide substituted with at least one electron withdrawing group, and preferably selected from p-nitrophenoxide, p-chlorophenoxide, o-chlorophenoxide, 2,4-dinitrophenoxide and pentafluorophenoxide.