A syringe (1) comprises a barrel (2) with a plunger (3) in slidable and sealing engagement therein, and a needle attached to one end of the barrel (2). The barrel (2) has aspiration means (13) in the form of manually-operable resilient portions (13), which can be operated to cause a pressure differential in the barrel (2), the pressure differential then being used to perform aspiration. The resilient portions (13) are preferably formed by localised reductions (15) of wall thickness in the external surface of the barrel (2).
