The disclosure relates to a family of compounds that are derivatives of sulindac (abstract figure). The disclosure also relates to the method of manufacture of these compounds for treatment of cancer, chronic inflammatory disease or neurodegenerative disease and a method of preparing the compounds. Example compounds include: (Z)-2-(5-fluoro-2-methyl-1-4-(methylthio)benzylidene)-1H-inden-3-yl)-N-(2-(piperidin-1-yl)ethyl)ethanamine (Z)-N-benzyl-2-(5-fluoro-2-methyl-1-(pyridine-4-ylmethylene)-1H-inden-3-yl)ethanamine (Z)-1-(5-Fluoro-2-methyl-1-(4-(methylthlo)benzylidene)-1H-inden-3-yl)-N,N-bis(pyridin-4-ylmethy)methanamine
