Methods, compositions, and methods for making compositions for reducing crop injury by applying to crops a composition containing one or more safeners and an herbicide composition containing a protoporphyrinogen oxidase (PPO) inhibitor are disclosed. In particular aspects, the safener composition contains cloquintocet-mexyl and/or mefenpyr-diethyl.本文揭示用於藉由將含有一或多種安全劑之組合物及含有原紫質原氧化酶(PPO)抑制物之除草劑組合物施加至作物而減少作物損害之方法、組合物及製取組合物之方法。在特定態樣中,該安全劑組合物含有解草酯(cloquintocet-mexyl)及/或吡唑解草酯(mefenpyr-diethyl)。無