STEPHEN ALAN FAKHOURY,HELEN TSENWHEI LEE,JESSICA ELIZABETH REED,KEVIN MATTHEW SCHLOSSER,KAREN ELAINE SEXTON,HAILE TECLE,ROY THOMAS WINTERS
申请号：
PT05732761
公开号：
PT1746999E
申请日:
2005.04.25
申请国别(地区):
PT
年份:
2012
代理人:
摘要：
This invention provides quinazoline compounds of the formula: wherein: R1 is halo R2 is H or halo R3 is a) C1-C3 alkyl, optionally substituted by halo or b) &mdash(CH2)n-morpholino, &mdash(CH2)n-piperidine, &mdash(CH2)n-piperazine, &mdash(CH2)n&mdash-piperazine-N(C1-C3 alkyl), &mdash(CH2)n-pyrrolidine, or &mdash(CH2)n-imidazole n is 1 to 4 R4 is &mdash(CH2)m-Het Het is morpholine, piperidine, piperazine, piperazine-N(C1-C3 alkyl), imidazole, pyrrolidine, azepane, 3,4-dihydro-2H-pyridine, or 3,6-dihydro-2H-pyridine, each optionally substituted by alkyl, halo, OH, NH2, NH(C1-C3 alkyl) or N (C1-C3 alkyl)2 m is 1-3 and X is O, S or NH or a pharmaceutically acceptable salt thereof, as well as processes and intermediate compounds for making them, useful pharmaceutical compositions and methods of using the compounds in the treatment of proliferative diseases.
