SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION; LTD.;BAIKSAN CO.;BAIKSAN CO., LTD.
发明人:
HEE JIN KIM,JI UNG PARK,JI YEON HAM,SUK WHA KIM,TAE HYUN CHOI,YAN LEE
申请号：
BR112016024206
公开号：
BR112016024206A2
申请日:
2015.04.17
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
patent summary for: "cross-linked polyphosphorylcholine coated in vivo prosthesis". The present invention relates to an in vivo implantable prosthesis coating composition which includes a photoinitiator, a crosslinking agent and a phosphorylcholine (pc) monomer having an acrylate group, a method of coating an in vivo implantable prosthesis uses the coating composition and an aesthetic prosthesis coated with cross-linked polyphosphorylcholine. Cross-linked polyphosphorylcholine coated in vivo implantable prosthesis can be fabricated by a simple method of applying a coating composition that includes a photoinitiator, a crosslinking agent and a phosphorylcholine (pc) monomer having an acrylate group according to the invention. present invention and then UV irradiation. The cross-linked polyphosphorylcholine coating can impart surface hydrophilicity and can also markedly reduce protein and fibroblast adsorption, which can cause side effects, such as capsular contracture. furthermore, the coating is strong enough not to peel off even under stimulation and is therefore maintained under vigorous activity after implantation, thus being beneficially applied to the manufacture of an in vivo implantable prosthesis with reduced side effects such as a prosthesis. of breast for cosmetic surgery.resumo da patente de invenção para: ?prótese para inserção in vivo revestida com polifosforilcolina reticulada?. a presente invenção se refere a uma composição de revestimento para uma prótese implantável in vivo que inclui um fotoiniciador, um agente de reticulação e um monômero de fosforilcolina (pc) que tem um grupo acrilato, um método de revestimento de uma prótese implantável in vivo que usa a composição de revestimento e uma prótese estética revestida com a polifosforilcolina reticulada. prótese implantável in vivo revestida com polifosforilcolina reticulada pode ser fabricada por meio de um método simples de aplicação de uma composição de revestimento que inclui um fotoiniciador, um
