Centre National de la Recherche Scientifique (CNRS)
发明人:
Chevalier, Yves,Agusti, Geraldine,Nyffenegger, Coralie,Doelker, Eric,Jordan, Olivier,Andersen, Gert
申请号：
AU2011226138
公开号：
AU2011226138A1
申请日:
2011.03.09
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The invention concerns a radiopaque, non-biodegradabie, water-insoluble iodinated benzyl ether of polyvinyl alcohol) consisting of a PVA having covalentiy grafted thereon iodinated benzyl groups comprising 1 - 4 iodine atoms per benzyl group, a process for preparing the same comprising reacting a 0 - 100 % hydrolyzed PVA with a iodinated benzyl derivative comprising 1 - 4 iodine atoms per benzyl group in a polar aprotic solvent in the presence of a base in anhydrous conditions. Said iodo-benzylether-PVA is particularly useful as embolic agent in an injectable embolizing composition. The invention also concerns an injectable embolizing composition comprising said iodo-benzylether-PVA and capable of forming a cohesive mass upon contact with a body fluid by precipitation of the iodo- benzylether-PVA. Said injectable embolizing composition is particularly useful for forming in-situ a cohesive mass in a blood vessel or into a tumor. The invention further concerns a coating composition containing said iodo-benzylether-PVA and capable of forming a radiopaque coating on a medical device. The invention further concerns particles formed of said iodo-benzylether-PVA.
