PROBLEM TO BE SOLVED: To provide a protein carbonylation inhibitor that is useful as an active ingredient of a skin external preparation for preventing and/or improving skin aging, specifically, reduced resilience and yellowing of skin.SOLUTION: The present invention provides a protein carbonylation inhibitor that contains deoxyribonucleic acids derived from testes of seafood as an active ingredient and a skin external preparation for preventing and/or improving skin aging that contains the protein carbonylation inhibitor.SELECTED DRAWING: NoneCOPYRIGHT: (C)2018,JPO&INPIT【課題】 皮膚老化、特に皮膚の弾力性低下や黄色化の予防および/または改善のための皮膚外用剤の有効成分として有用な、タンパク質のカルボニル化抑制剤を提供する。【解決手段】 魚介類精巣由来のデオキシリボ核酸を有効成分として含有するタンパク質のカルボニル化抑制剤並びにタンパク質のカルボニル化抑制剤を含有する、皮膚老化の予防および/または改善のための皮膚外用剤。【選択図】なし