University of Pittsburgh - Of the Commonwealth System of Higher Education
发明人:
Steven R. Little,Riccardo Gottardi,Mintai Peter Hwang,Daniel DeSantis
申请号：
US16241112
公开号：
US20190209651A1
申请日:
2019.01.07
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention provides microparticles that induce the migration of multipotent stem cells to the anatomical site of the microparticles. Various release profiles are demonstrated that depend upon the relative concentration of alginate in the chemokine-loaded microparticle. Local administration and/or intraarticular injection of the microparticles are useful in conditions such as osteoarthritis. Targeted systemic delivery of the alginate chemokine microparticles to distant anatomical sites subjected to autoimmune disease symptomology can be performed by encapsulation within liposomes having targeting ligands. Consequently, upon the creation of the appropriate chemokine gradient, multipotent stem cells will migrate to the distant anatomical site where the liposomes are attached.
