Christian Degering;Thorsten Eggert;Stefan Evers;Karl-Heinz Maurer;Johannes Bongaerts
发明人:
Christian Degering,Thorsten Eggert,Stefan Evers,Karl-Heinz Maurer,Johannes Bongaerts
申请号：
US14122562
公开号：
US09803183B2
申请日:
2012.05.25
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The aim of the invention is to improve the secretion of a protein from a host cell in order to increase the product yield of protein in a fermentation process. This is achieved by an expression vector comprising a promoter sequence and a nucleic acid sequence that codes for a protein. The protein comprises a signal peptide and an additional amino acid sequence, and the signal peptide comprises an amino acid sequence that is at least 80% identical to the amino acid sequence specified SEQ ID NO: 2, at least 80% identical to the amino acid sequence specified in SEQ ID NO: 4, at least 80% identical to the amino acid sequence specified in SEQ ID NO: 6, or the signal peptide comprises an amino acid sequence that is structurally homologous to at least one of said sequences.
