PROBLEM TO BE SOLVED: To provide a globose nucleus which has no physical properties variation, can be produced readily, and has swelling property, and to provide a film breakage type time-dependent release formulation which has a high precision, and can control drug dissolution readily.SOLUTION: The invention relates to a globose nucleus consisting of a mixture containing a crystalline cellulose and a swelling agent and a spherical base granule in which the surface of the globose nucleus is coated with a drug and a spherical granule in which the surface of the spherical base granule is coated with a water-insoluble substance.COPYRIGHT: (C)2015,JPO&INPIT【課題】物性バラツキがなく容易に製造可能な膨潤性を有する球状核、及び精度が高く容易に薬物溶出制御が可能な膜破裂型の時限放出製剤の提供。【解決手段】結晶セルロースと膨潤剤を含む混合物からなる球状核、及び球状核の表面が薬物で被覆された球形素顆粒、球形素顆粒の表面が水不溶性物質で被覆された球形顆粒。【選択図】なし
