Human recombinant monoclonal antibody that specifically binds to VCAM-1 and inhibits adhesion and transmigration between leukocytes and endothelial cells
Su Yeon Ryu;Dong Heon Lee;Jung Tae Lee;Ji Yong Yoon;Kyung Duk Moon;Dong Eun Lee;Byung Je Sung;Hyun Bo Shim;Kyung Jae Kang
发明人:
Jung Tae Lee,Kyung Duk Moon,Ji Yong Yoon,Byung Je Sung,Dong Heon Lee,Dong Eun Lee,Su Yeon Ryu,Hyun Bo Shim,Kyung Jae Kang
申请号：
US13503103
公开号：
US08623368B2
申请日:
2010.10.22
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to a human recombinant monoclonal antibody that specifically binds to human Vascular Cell Adhesion Molecule-1 (VCAM-1) to inhibit adhesion between leukocytes and activated endothelial cells and transmigration of leukocytes through the activated endothelial cells, and a prophylactic and therapeutic composition for inflammatory disease or cancer comprising the same. The human recombinant monoclonal antibody according to the present invention shows a strong affinity to VCAM-1 expressed on human endothelial cell, and effectively inhibits VCAM-1-mediated adhesion between leukocytes and activated endothelial cells and transmigration of leukocytes through the activated endothelial cells, thereby being used for the prevention and treatment of inflammatory disease such as asthma and arthritis, transplant rejection, cardiovascular disease, and cancer.
