KIM, SUNG WUK,김성욱,JUN, SUNG SOO,전성수,PARK, SEUNG KOOK,박승국,KIM, SONG YOUNG,김송영,KIM, EUN SUN,김은선,JEONG, JAE KAP,정재갑,KIM, HA NA,김하나,SONG, YEON JUNG,송연정
申请号：
KR1020110138751
公开号：
KR1020120072323A
申请日:
2011.12.21
申请国别(地区):
KR
年份:
2012
代理人:
摘要：
PURPOSE: A modified human tumor necrosis factorreceptor-1(TNFR-1) polypeptide which binds to TNF in vivo or in vitro or a fragment thereof is provided to improve the binding force to TNF and protease resistance. CONSTITUTION: A modified human TNF-1 polypeptide or a fragment thereof contains: amino acids having 5 modified amino acids including 92th, 95th, 97th, 98th amino acid residue and one amino acid residue selected from 68th, 161th, 200th, and 207th in wild type human TNFR-1 polypeptides of sequence number 1； amino acids having 5 modified amino acids including 92th, 95th, 97th, 98th amino acid residue and one amino acid residue selected from 68th, 161th, 200th and 207th in wild type TNFRI171； amino acids having 5 modified amino acids including 92th, 95th, 97th, 98th amino acid residue and one amino acid residue selected from 68th and 161th, in wild type TNFRI126； or amino acids having 5 modified amino acids including 68th, 92th, 95th, 97th, and 98th amino acid residues in wild type TNFRI105.본 발명은 생체내(in vivo) 또는 생체외(ex vivo)에서 종양 괴사 인자와 결합하는 변형된 인간 종양 괴사 인자 수용체-1(human tumor necrosis factor receptor-1) 폴리펩티드 또는 그의 절편을 제공한다. 본 발명의 변형된 인간 종양 괴사 인자 수용체-1 폴리펩티드 또는 그의 절편은 종양 괴사 인자에 대한 개선된 결합력 및 단백질 분해효소 저항성을 나타낸다.
