A medical port has a housing forming an interior with a fluid inlet and a fluid channel extending from the fluid inlet. The housing also has an exterior wall forming at least one radial opening to the interior. In addition to the housing, the medical port also has a resilient valve element within the housing interior configured to control fluid flow through the inlet, and a biasing element movably couplable with the housing. The resilient valve element has a proximate body portion proximate to the radial opening when in the closed mode. The biasing element also has a constraining portion configured to cooperate with the radial opening to contact at least the proximate body portion of the valve element when in the closed mode. The biasing element constraining portion preferably is configured to normally resist radial outward movement of the proximate body portion when in the closed mode.