DE MAN Adrianus Petrus Antonius (NL),ДЕ МАН Адрианус Петрус Антониус (NL),BUIJSMAN Rogier Christian (NL),БЁЙСМАН Рогир Христиан (NL),STERRENBURG Jan Gerard (NL),СТЕРРЕНБУРГ Ян Герард (NL),UITDEHAAG Jo
申请号：
RU2016141405
公开号：
RU0002692479C2
申请日:
2015.03.30
申请国别(地区):
RU
年份:
2019
代理人:
摘要：
FIELD: chemistry.SUBSTANCE: invention relates to a compound of formula I or a pharmaceutically acceptable salt thereof, where R1 is selected from a group consisting of:R11 is H, halogen, (1-2C)alkyl, (1-2C)alkoxy or OC2H3, where all alkyl and alkoxy groups are optionally substituted with one or two halogens； R12 is H； R13 is R132O, R133R134N, R135C(O), (2-7C)heterocycloalkyl selected from piperidinyl, piperazinyl, morpholinyl or azetidinyl, or (1-5C)heteroaryl, selected from pyrazolyl or isoxazolyl, where each heterocycloalkyl or heteroaryl is optionally substituted with 1-3 substituents (1-2C)alkyl, (1-2C)alkoxy, (1-6C)alkylcarbonyl, (1-6C)alkylsulfonyl, (1-5C)alkoxycarbonyl, (1-6C)alkylaminocarbonyl, (3-6C)cycloalkylcarbonyl or (2-7C)heterocycloalkylcarbonyl, in which said heterocycloalkyl is selected from azetidinyl or oxetanyl, where each alkylcarbonyl, cycloalkylcarbonyl or heterocycloalkylcarbonyl is optionally substituted with (1-2C)alkyl, fluoro or (1-2C)alkoxy； R132 is (1-6C)alkyl or (2-7C)heterocycloalkyl selected from piperidinyl, pyrrolidinyl, azetidinyl or tetrahydropyranyl, each of which is optionally substituted with one group selected from (1-2C)alkyl, (1-2C)alkoxy or di[(1-2C)alkyl]amino； R133 is (1-6C)alkyl, optionally substituted with one group selected from di[(1-2C)alkyl]amino； R134 is hydrogen or (1-2C)alkyl； R135 is (2-7C)heterocycloalkyl selected from morpholine, thiazinane, diazepane or piperidine； (1-6C)alkylamino； di[(1-6C)alkyl]amino； (2-7C)heterocycloalkylamino, wherein said heterocycloalkyl is selected from piperidine, tetrahydropyran, azetidine and oxabicyclohexane； or (3-6C)cycloalkylamino, each of which is optionally substituted with one or two groups selected from (1-2C)alkyl, fluorine, hydroxyl, (1-2C)alkoxy, di[(1-2C)alkyl]amino, piperidinyl, oxo, cyano or amino； R14 is H, halogen or (1-2C)alkyl； R15 is H； R2 is selected from a group consisting of:R21 is H, halogen, (1-3C)alkyl, (1-2C)alkoxy, hydroxy(1-2C)alkyl or cyano； R22 is H；
