Ratima SUNTORNNOND,Jia AN,Chee Kai CHUA,Edgar Yong Sheng TAN,Wai Yee YEONG,Jie Kai ER
申请号：
US16490034
公开号：
US20200009298A1
申请日:
2018.03.01
申请国别(地区):
US
年份:
2020
代理人:
摘要：
A hydrogel composite is provided. The hydrogel composite comprises a modified poloxamer having a first charge moiety and a peptide having a second charge moiety, wherein the first charge moiety and the second charge moiety are oppositely charged for ionic interaction between the modified poloxamer and the peptide, and wherein at least one of the modified poloxamer and the peptide comprises a crosslinkable moiety. In particular, the modified poloxamer is a pluronic monocarboxylate activated by dimethylaminopyridine and triethanolamine； the peptide is a gelatin methacrylate. A bioshaping method using the hydrogel composite is provided, as well as a three-dimensional network obtained by the bioshaping method.
