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Tricyclic indoles and (4,5-dihydro) indoles
专利权人:
Marina Caldarelli;Alessandra Scolaro;Maria Menichincheri;Paola Vianello;Barbara Forte;Francesco Casuscelli;Gabriella Traquandi;Ermes Vanotti
发明人:
Ermes Vanotti,Marina Caldarelli,Francesco Casuscelli,Barbara Forte,Maria Menichincheri,Alessandra Scolaro,Gabriella Traquandi,Paola Vianello
申请号:
US12516712
公开号:
US08207180B2
申请日:
2007.11.23
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present invention provides tricyclic indoles and (4,5-dihydro) indoles of the formula (I) or a pharmaceutically acceptable salt thereof: wherein the ring A represents a fused pyrazole, pyridine or pyrimidine, means either simple or double carbon-carbon bond and R1, R2 and R3 are as defined in the specification. Further objects of the invention are a process for the preparation of the compounds of the formula (I), pharmaceutical compositions comprising them and methods for treating cell proliferative disorders. As a matter of fact, the compounds of the formula (I) are useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, in particular Cdc7 and AKT kinase activity, like cancer.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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