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Human anti-ngf neutralizing antibodies as selective ngf pathway inhibitors
专利权人:
MEDAREX L.L.C.;AMGEN INC.
发明人:
TREANOR JAMES J.S,MARTIN FRANK,WILD KENNETH D,HUANG HAICHUN,INOUE HEATHER,ZHANG TIE J
申请号:
NZ62539110
公开号:
NZ625391A
申请日:
2010.10.08
申请国别(地区):
NZ
年份:
2016
代理人:
摘要:
Discloses use of an NGF antibody in the manufacture of a medicament for treating pain that is associated with a condition caused by increased expression of nerve growth factor (NGF) or increased sensitivity to NGF, wherein the antibody is to be administered in a pharmaceutical composition comprising: a pharmaceutically acceptable carrier and the isolated antibody, wherein the antibody comprises a light chain comprising SEQ ID NO: 44 and a heavy chain comprising SEQ ID NO: 40; wherein the NGF antibody is to be administered by subcutaneous injection, wherein the subcutaneous injection comprises multiple subcutaneous injections; wherein the NGF antibody dose is from 3 mg to 30 mg per subcutaneous injection, wherein the sequences are as defined in the complete specification.
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