Amphipathic and other double-sided alpha-helix mimetics based on a 1,2-diphenylacetylene scaffold

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专利权人:

发明人:

Steven Fletcher

申请号：

US14200774

公开号：

US08901164B2

申请日:

2014.03.07

申请国别(地区):

US

年份:

2014

代理人:

摘要：

Small-molecule scaffolds based on 1,2-diphenylacetylene that accurately replicate the spatial and angular projections of several side chains on both faces of an α-helix, specifically the i and i+7 side chains on one face, and the i and i+2 side chains on the other. The amphipathic α-helix mimetic can be used to disrupt disease-promoting protein-protein interactions that are mediated by α-helices.

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中国工程科技知识中心

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