PROBLEM TO BE SOLVED: To provide compositions such as a pharmaceutical, a food and beverage, etc., for fundamentally preventing, improving or treating eye disease or neuropathy which is difficult to be treated until now, by finding a substance having differentiation-inducing activity from stem cells to ectodermal cells.SOLUTION: This differentiation inducer from stem cells to ectodermal cells includes lignin as an active ingredient. The ectodermal cells are sense organ system cells or nervous system cells.COPYRIGHT: (C)2013,JPO&INPIT【課題】幹細胞から外胚葉系細胞への分化誘導活性を有する物質を見出し、これまで治療が困難であった眼疾患や神経疾患を根本的に予防、改善または治療するための医薬品や飲食品などの組成物を提供すること。【解決手段】リグニンを有効成分として含有する、幹細胞から外胚葉系細胞への分化誘導剤。【選択図】なし