Scott R. Gilbertson;Anton Agarkov;Vladimir L. Motin;Sadhana Chauhan;Pedro Lory
发明人:
Vladimir L. Motin,Sadhana Chauhan,Scott R. Gilbertson,Anton Agarkov,Pedro Lory
申请号：
US13199407
公开号：
US09187523B2
申请日:
2011.08.29
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention is directed to peptide sequences that were identified from combinatorial libraries and could serve as substrates of plague plasminogen activator (Pla). Another aspect of the present invention is drawn to peptides derived from the substrates for Pla as a result of chemical modifications leading to specific inactivation of the proteolytic activity of Pla. Additionally, the present invention is directed to the use of the substrates identified herein in the detection of bacteria expressing omptin family of proteases which includes Y. pestis. Furthermore, the present invention is also directed to the use of the inhibitors identified herein in the prevention and treatment of infection caused by these bacteria.
