DÉRIVÉS DE BENZOTHIOPHÈNE ET COMPOSITIONS CORRESPONDANTES EN TANT QU'AGENTS DE DÉGRADATION SÉLECTIFS DES RÉCEPTEURS DES ESTROGÈNES

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专利权人:

Novartis AG

发明人:

申请号：

EP18156411.3

公开号：

EP3360870A1

申请日:

2014.02.12

申请国别(地区):

EP

年份:

2018

代理人:

摘要：

The present invention relates to compounds of formula I:in which n, m, X, Y1, R1, R2, R3, R4 and R5 are defined in the Summary of the Invention； capable of being both potent antagonists and degraders of estrogen receptors. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with aberrant estrogen receptor activity.

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