GEORG DR. KETTSCHAU,FLORIAN DR. PHLER,KNUT DR. EIS,ULRICH DR. KLAR,DIRK DR. KOSEMUND,DETLEV DR. SLZLE,PHILIP DR. LIENAU,ANDREA DRA. HGEBARTH,ULF DR. BMER
申请号：
ARP130101735
公开号：
AR091093A1
申请日:
2013.05.20
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
Tienopirimidina substituted compounds of the General formula (1) are described and defined in the present Methods of preparing such Compounds, compounds, Intermediates useful for preparing such compounds.Pharmaceutical compositions and combinations comprising these compounds and the use of these compounds in the preparation of a Pharmaceutical composition for the Treatment or prophylaxis of disease, in particular of a disorder hiperproliferativo and / or angiogenesis, as Agent Only or in combination with other active ingredients.Claim 1: a compound of General formula (1) wherein: r u00b9 represents a group selected from (- C (= o) or r u00b3 -, - C (= o) n (H) r u00b3, - C (= o) nr u00b3r u2074； r u00b2 u1d43, r u00b2 u1d47, r u00b2 u1d9c, r u00b2 u1d48 represent, independently between Yes, a Hydrogen Atom or a group selected from alkyl c u2081: u208b u2083 c u2081 u208b u2083, Hydroxy, alkoxy, Halo, Halo - Halo - c u2081 u208b u2083 c u2081 u208b u2083 alkyl, alkoxy, cyano, - N (H) r u2075,- nr u2075r u2074； r u00b3 represents a hydrogen Atom or a group selected from c u2081 u208b u2086: rent, alquenilo c u2082 u208b u2086, alquinilo c u2082 u208b u2086, (ch u2082 Q - (-) - (ch u2082 cycloalkyl c u2083 u208b u2087), Q () - or - (ch u2082 cycloalkyl c u2083 u208b u2087) - Q () - cicloalquenilo c u2084 u208b u2087) - Q (ch u2082) - (cicloalquenilo c u2084 u208b u2087 - (ch u2082), Q () - heterocicloalquilo between 3 and 10 members) - Q (ch u2082) - or - (heterocicloalquilo between 3 and 10 members)- (ch u2082) - Q (heterocicloalquenilo between 4 and 10 members) - Q (ch u2082) - or - (heterocicloalquenilo between 4 and 10 members) - (ch u2082) - aryl - (Q, Q ch u2082) - or - (aryl, heteroaryl ch u2082) - Q (-, - ch u2082) Q - or - heteroaryl； where the selected Group is a Group r u2074 represents optionally substituted； Selection Held between c u2081 u208b u2086: rent, alquenilo c u2082 u208b u2086, alquinilo c u2082 u208b u2086, c u2081 u208b u2086 Halo alkyl, Hydr
