The Board of Trustees of the Leland Stanford Junior University
发明人:
Chia Chi Ho,Kenan Christopher Garcia,Aaron Michael Ring,Kipp Andrew Weiskopf,Irving L. Weissman,Nan Guo Ring
申请号：
US15569007
公开号：
US20180127480A1
申请日:
2016.05.05
申请国别(地区):
US
年份:
2018
代理人:
摘要：
High affinity CD47 reagents are provided, which (i) comprise at least one amino acid change relative to the wild-type protein； and (ii) have an increased affinity for a SIRPα relative to the wild-type protein. Compositions and methods are provided for modulating phagocytosis in a mammal by administering a therapeutic dose of a pharmaceutical composition comprising a high affinity CD47 reagent, which blocks the physiological binding interaction between SIRPα and a ligand, e.g., native CD47.
