The present invention relates to a wheelchair comprising a frame (1) and two main wheels (10, 20) each coupled to a handrail (11, 21) for actuating said wheels in both directions of rotation and for braking. Said frame (1) is equipped with: • on the right side with respect to the direction of normal movement ○ a connecting means (15) of a lateral axis (13) blocking in the clockwise direction and free in rotation in the direction anti-clockwise ○ the right wheel (10) being provided with a hub (12) connected to said handrail (11) by a blocking means in the clockwise direction ○ said hub comprising means for braking the rotation of said hub with respect to said lateral axis, actuated by the anti-clockwise movement of said handrail relative to said lateral axis • on the left side with respect to the direction of normal movement ○ of a connecting means (25) of a lateral axis ( 23) counter-clockwise and freely rotatable in the clockwise direction ○ the left wheel (20) being provided with a hub (22) connected to said running hand by a counterclockwise locking connection means Said hub (22) comprising means for braking the rotation of said m oyeu relative to said lateral axis, actuated by the hourly displacement of said handrail relative to said lateral axis. La présente invention concerne un fauteuil roulant comportant un cadre (1) et deux roues principales (10, 20) accouplées chacune à une main courante (11, 21) pour l'actionnement desdites roues dans les deux sens de rotation et pour le freinage. Ledit cadre (1) est équipé : • du coté droit par rapport à la direction de déplacement normale ○ d'un moyen de liaison (15) d'un axe latéral (13) bloquant dans le sens horaire et libre en rotation dans le sens anti-horaire ○ la roue droite (10) étant munie d'un moyeu (12) relié à ladite main courante (11) par un moyen de liaison bloquant dans le sens horaire ○ ledit moyeu comportant un moyen de freinage de la rotation dudit moyeu par rapport audit a