A method and an electrode for monitoring electrical activity in a nerve are provided along with a method of fabricating such an electrode. The electrode includes a cuff formed from a chronically-implantable material that, when implanted, extends at least partially around an external periphery of the nerve. A plurality of contacts are supported by the cuff to be arranged adjacent to different regions of the nerve distributed along a transverse direction of the nerve when the cuff is implanted. A multiplexer is coupled to the cuff to be implanted for receiving electrical signals introduced to the contacts by the nerve and multiplexing, in vivo, the electrical signals to be transmitted to an external receiver over a shared communication channel.
